In fact, on analyzing the patients’ characteristics in the device group at baseline, it was noted that 82.2% had an LVEF below 40%, 58% had experienced a HF-related hospitalization within the previous year, 54% were in NYHA class III, and the mean level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) was 5,174.3 ± 6,566.6 pg/ml (18). This evidence concerns the gene NPPB and hydrops fetalis.