The results showed that ITGB6 and Rac1 were highly expressed in gastric cancer tissues (H-score, 33.87 ± 22.15, 46.99 ± 24.23, respectively) and lymph node metastases (H-score, 36.73 ± 23.69, 50.29 ± 25.96, respectively) compared with adjacent normal tissues (H-score, 22.52 ± 5.61, P<0.001; 40.13 ± 15.37, P<0.001, respectively) and non-metastatic tissues (H-score, 25.60 ± 14.19, 37.44 ± 14.91, respectively, Figures 2A–D). Here, RAC1 is linked to gastric cancer.