In the context of cancer, ITGB6 has been demonstrated to facilitate tumor progression and metastasis by regulating the signaling pathway of transforming growth factor-beta (TGF-beta) and promoting epithelial-mesenchymal transition (EMT), a cellular process in which epithelial cells undergo a transformation into a mesenchymal phenotype, promoting increased cellular motility and invasiveness (7, 8). This evidence concerns the gene ITGB6 and cancer.