CRH and epilepsy: Different hormones have distinct effects on seizures: glucocorticoid levels are elevated in epilepsy patients, while deoxycorticosterone, an anticonvulsant drug, exhibits beneficial effects; Corticotropin-releasing hormone (CRH) and corticosterone promote the signaling of excitatory neurotransmitters like glutamate, which can induce seizures (Baram and Schultz, 1991; Reddy and Rogawski, 2002; Werner and Coveñas, 2017).