Of note, microglial NRLP3 inflammasome activation is critical for dopaminergic neuronal loss in a murine model of Parkinson’s disease (37) and we have recently shown an increased mRNA and protein expression of the P2X7R-NLRP3 inflammasome in lymphomonocytes of treatment-naïve Parkinson’s disease subjects, suggesting that even extra-neural P2X7R might be relevant in the early phase of the disease (38). The gene discussed is NLRP3; the disease is Parkinson disease.