In a rat model of PD, the activation of P2X7R promotes death of nigrostriatal dopaminergic neurons, and its inhibition by Brilliant Blue G attenuates microglial activation and loss of dopaminergic neurons (34); another report shows as P2X7R antagonism can revert hemiparkinsonian behavior and increases the immunoreactivity for tyrosine hydroxylase in the Substantia Nigra (35). Here, TH is linked to Parkinson disease.