MAPT and Alzheimer disease: Various etiological mechanisms have been proposedfor AD, includingthe decrease of the KGDHC activity, the deposition of Aβ, theaggregation of Tau protein, the increase of oxidative stress, andthe reduction of ACh.21,53 In this study, our results suggestthat the decrease in the KGDHC activity and the increase in the oxidativestress may share a common mechanism for the etiology of AD.