MAPT and Alzheimer disease: High oxidative stress hasbeen shown to promote the deposition of Aβ4254 and lead to the hyperphosphorylation of Tau protein, whichcould result in the instability and dissociation of the microtubulesin the brain and ultimately lead to the oligomerization of Tau protein.54 The oxidative stress has also been considereda key modulator in neurodegenerative diseases, including AD.30 In this study, the results showed that parapyruvatecould induce the aggregation of Tau and p-Tau, and the increase ofthe AChE activity, supporting the crucial role of the oxidative stressin the etiology of AD.