The neurotoxicity of DG is commonly used asa model for drug screeningfor the brain aging,40,41,55−58 or for AD.59,60 The continuous subcutaneous administrationof DG in mice was also found to induce an increase in the AChE activityin the brain.59 However, in this study,we used 120 mg/kg/day of DG administered subcutaneously 5 times perweek, and the results showed that DG only significantly decreasedthe KGDHC activity in the C57BL/6JNarl mice. Here, ACHE is linked to Alzheimer disease.