UBC and amyotrophic lateral sclerosis: The bigenic Cre::Tdp-43ΔNLS mice suffered from progressive motor dysfunctions, gait asymmetry, early-stage myogenic ALS pathology, and MN degeneration, simultaneously, pTDP- 43- and ubiquitin- positive pathology in the dorso-lateral and dorso-ventral spinal cord, reflected early ALS symptoms [62].