UBC and amyotrophic lateral sclerosis: Next, we established the Tdp-43ΔNLS ALS model by crossing heterozygous Tdp-43ΔNLS+/− mice with TAM-inducible Ubc (whole-body) or Mnx1 (MN-specific) promoter-driven Cre+/− mice as shown in schematics (Fig. 2c-d).