Surprisingly, of the 37 genes significantly associated with AD in both datasets, six had the opposite directions: PTPRG, ACOT11, DDB1 and ZNRD1ASP were up-regulated with AD in microglia but down-regulated in the brain homogenate analyses, while YES1 and KANK2 had the opposite pattern (Fig. 2g right). This evidence concerns the gene KANK2 and Alzheimer disease.