Transcriptional changes associated with AD diagnosis based on CERAD score (Fig. 2d, Extended Data Fig. 5a) include the up-regulation of PTPRG, IL15, APOE, and down-regulation of CECR2, SELENBP1, ASTN1, MEIS1, and TNFRSF21, both with and without Age in the model for our analyses (Extended Data Fig. 6, Supplementary Fig. 3, Supplementary Fig. 4). Here, ASTN1 is linked to Alzheimer disease.