APOE and Alzheimer disease: Transcriptional changes associated with AD diagnosis based on CERAD score (Fig. 2d, Extended Data Fig. 5a) include the up-regulation of PTPRG, IL15, APOE, and down-regulation of CECR2, SELENBP1, ASTN1, MEIS1, and TNFRSF21, both with and without Age in the model for our analyses (Extended Data Fig. 6, Supplementary Fig. 3, Supplementary Fig. 4).