Importantly, the ‘within-control’ and ‘within-AD’ stratification shares with same axis, with distinct molecular states from gene set variance analysis 43 based on DEGs from AD diagnoses, (CERAD) and (Clinical), amyloid β plaque density, ApoE4 allele counts, and Braak stage (High vs. Middle) (Fig. 6d, Extended Data Fig. 10). This evidence concerns the gene APOE and Alzheimer disease.