Biologically, processes associated with the genes whose relationship with PTPRG is dysregulated in AD include stress response, MYC activity, inflammatory response via TNFα/NFκB, granules and exocytosis, actin activity, NK-cell activity, as well as multiple aspects of the translational machinery (Fig. 4c, Supplementary Fig. 7c). Here, NFKB1 is linked to Alzheimer disease.