The same genes have comparable association with Braak stage (Extended Data Fig. 3, Supplementary Table 1), whereas PTPRG and SELENBP1 is less strongly associated with clinical dementia (Log2FC AgeModel: for PTPRG: AD (CERAD) = 1.64, Braak Stage (High vs. Low) = 1.89, Dementia (CDR) = 0.85; for SELENBP1: AD (CERAD) =−1.39, Braak Stage (High vs. Low) =−1.28, Dementia (CDR) =−0.83). The gene discussed is SELENBP1; the disease is Alzheimer disease.