SOX2 and early-onset autosomal dominant Alzheimer disease: Oh et al. 69 attributed the ASC-mediated increased of Sox2 expression in NSCs through the activation of Wnt signaling pathway in a model of Alzheimer’s Disease, while Munoz et al. 57 demonstrated that the transplantation of BMSCs into the dentate gyrus of immunodeficient mice increased the proliferation of endogenous Sox2+ NSC cells, due to a local increase of VEGF, Ciliary neurotrophic factor (CNTF), NT4/5 and NGF.