PLG and multiple sclerosis: PLG and PLAU have also been described to contribute to the inflammatory response in several CNS inflammation and demyelination contexts, usually closely related to activation of matrix metalloproteinases (MMPs).123 For example, in multiple sclerosis, PLG and its receptor were highly concentrated on inflammatory cells in acute lesions, facilitating its infiltration into the CNS through the action of specific MMPs, namely MMP9 and MMP1.123