In endometrial carcinoma, demethylase activity of ALKBH5 can inhibit the decay of IGF1R transcript and promote the expression of IGF1R (insulin-like growth factor 1 receptor), thereby inducing the expression of COL1A1(collagen type I alpha 1 chain) and MMP9(matrix metallopeptidase 9) which enhances the proliferation, invasion, and migration of endometrial cells (47). The gene discussed is IGF1R; the disease is endometrial carcinoma.