During the aerobic glycolysis of cancer cells, Pyruvate dehydrogenase kinase 4 (PDK4) is one of the most important factors which can direct carbon flux into glycolysis from oxidative phosphorylation (OXPHOS) (23) and HK2 (hexokinase 2) is a key rate-limiting enzyme in aerobic glycolysis (24). Here, PDK4 is linked to cancer.