Either the mutation of METTL14 or the downregulation of METTL3 expression can impact on the mRNA stability of PHLPP2 (PH domain and leucine rich repeats protein phosphatase 2) and mTORC2 (Mechanistic target of rapamycin kinase complex 2) that the key members within the AKT pathway which leads to the activation of the AKT signaling pathway and promotes the proliferation, invasion, metastasis, and colony formation of endometrial cancer cells (35). This evidence concerns the gene METTL3 and endometrial cancer.