As previous results obtained in squamous cells carcinoma showed that RND3 potentiates NOTCH signaling by favoring translocation of the intracellular domain of NOTCH1 to the nucleus [25], and considering that the expression of NOTCH1 is increased during macrophage activation [30], we tried to evaluate the role of NOTCH1 in RND3 potentiation of NOTCH signaling. The gene discussed is NOTCH1; the disease is squamous cell carcinoma.