However, in addition to the widely accepted stemness-related markers CST7, CCR7 and TCF7, other cluster-specific markers of CD8.c05, such as SIPR1 and ENC1 (Figure 1I, Supplementary Figure S2A), as well as MPR-enriched DEGs such as PTGER4 and SRSF2 (Figure 1G), still lacked certain research related to their roles in tumor immunology, which made the features of CD8.c05 even more unclear. This evidence concerns the gene ENC1 and neoplasm.