CD8A and non-small cell lung carcinoma: In contrast, precursor-exhausted CD8+ TILs (Tpex) with high GZMK expression and diminished ICs accumulated within the responsive (R) TME after chemo+nivo in non-small cell lung cancer (NSCLC) (11), while the nonresponsive (NR) TME was filled with exhausted Trm cells instead.