Furthermore, the percentage of antibody-secreting CD19+CD38+CD27+ plasma cells also decreased in the adenoma grade II group (2.775 vs. 0.405, P < 0.0001), adenoma grade III group (2.775 vs. 1.230, P = 0.0015), and CRC group (2.775 vs. 1.280, P = 0.0155) compared with that in the control group (Figure 6C). Here, CD38 is linked to colorectal carcinoma.