Compared with the control, IL-22 levels were lower in HPs (4.93 vs. 1.76, P = 0.0163), adenoma grade II (4.93 vs. 1.66, P = 0.0059), and CRC (4.93 vs. 1.28, P = 0.0095) (Figure 4F). Here, IL22 is linked to colorectal carcinoma.