To further elucidate the key genes involved in the progression of SSc, we conducted PPI network analysis and identified 10 hub genes: KIF20A, KIF11, UBE2C, BUB1B, CDK1, CCNB2, AURKB, TOP2A, PLK1, and NCAPG. The gene discussed is UBE2C; the disease is systemic sclerosis.