TLR3 and neoplasm: In addition to its canonical antiviral activity, TLR3 was recently reported as a potential mechanism for inducing antitumor immunity, as the expression of TLR3 dramatically increases the expression of IFN-λ1 by cDC1s (conventional type 1 dendritic cells) and promotes tumor-inhibitory CTL (cytotoxic T lymphocyte) responses (99).