Recent analysis revealed that two SNPs (c.1118A>C [p.Glu373Ala] and c.803G>T [p.Cys268Phe]) in DDX58 (encoding RIG-I) can increase IFN and ISG expression, causing SGMRT2 (Singleton-Merten syndrome-2) to lead to glaucoma, aortic calcification, and skeletal abnormalities, indicating an important role in autosomal-dominant multisystem disorders (10). The gene discussed is RIGI; the disease is calcification.