Previous studies showed that MCM2 and MCM7 promote hepatocellular carcinoma cell stemness and tumor progression via hippo signaling and cyclin D1-dependent signaling, respectively, and overexpression of them correlates with poor prognosis in HCC (Zhou et al., 2012; Qu et al., 2017; Tang et al., 2022; Zhou et al., 2022). The gene discussed is CCND1; the disease is neoplasm.