They also had a role in polarizing macrophages to an anti-inflammatory phenotype, alleviating lipopolysaccharide (LPS)-induced reactive oxygen species (ROS) accumulation, expression of inflammatory factors such as IL-1β, TNF-α, and IL-6, relieving LPS-induced inflammation, and improving the inflammatory response and damage of multiple organs in sepsis (21). This evidence concerns the gene TNF and Sepsis.