NLRP3 and cryopyrin-associated periodic syndrome: Genetic variations in NLRP12 cause NLRP12-AID (11), aka Familial Cold Autoinflammatory Syndrome Type 2 (FCAS2) due to its similarity to FCAS1 and MWS, and both NLRP12-AID and CAPS are phenotypically characterized by conjunctivitis, urticaria and arthralgias triggered by exposure to cold, as well as neurosensory hearing loss (11).