Wnt/β-catenin signaling is a major androgen signal, and the androgen receptor has also been reported in osteosarcoma, is considered as a novel potential prognostic marker in osteosarcoma [21] and has interaction with another important steroid receptor, FXR [22], which in turn is an important regulator of FOXO and tumorigenesis [23]. Here, NR1H4 is linked to osteosarcoma.