In this study, we observed increased methylation levels in the promoter region of METTL7A in 11 type of cancers from TCGA, and METTL7A were downregulated in these cancers, suggesting that hypermethylation of METTL7A promoter may contribute to the down-regulation of METTL7A in these tumors. The gene discussed is TMT1A; the disease is cancer.