Similar circumstance, treatment with OME as a reference drug revealed a similar increase in Nrf2 (18.13% and 8.24%; p > 0.05) and HO−1 (21.3%; p <0.01 and 17.07%; p > 0.05) when associated with the E and RE groups, respectively (Fig. 7). The gene discussed is NFE2L2; the disease is otitis media with effusion.