Similar circumstance, treatment with OME as a reference drug revealed a similar increase in Nrf2 (18.13% and 8.24%; p > 0.05) and HO−1 (21.3%; p <0.01 and 17.07%; p > 0.05) when associated with the E and RE groups, respectively (Fig. 7). Here, HMOX1 is linked to otitis media with effusion.