In gliomas, T cell immunoglobulin and mucin domain-containing protein 3 (TIM-3) works against the inflammatory response and inhibits T-cell-mediated immunity, which is critical for tumor defense, thus the expression of TIM-3 on T cells and various immune cells has been correlated with poor prognosis across various tumor types [97]. This evidence concerns the gene HAVCR2 and central nervous system cancer.