Accordingly, the National Comprehensive Cancer Network recommends that the KRAS/NRAS/BRAF genotypes in metastatic CRC patients be determined [9], and has approved both panitumumab and cetuximab as anti-EGFR monoclonal antibodies for the treatment of metastatic CRC caused by KRAS/NRAS/BRAF wild-type tumors [10, 11]. This evidence concerns the gene NRAS and colorectal carcinoma.