Previous research have shown that the long noncoding RNA (lncRNA) cancer susceptibility candidate gene 2 (CASC2), which is found on chromosome 10 of the human genome, inhibits inflammation and sepsis-induced multi-organ damage through a variety of signaling pathways, and inflammation caused by the NF-kB signaling pathway was observed to be inhibited by the lncRNA CASC2 in human renal tubular epithelial cells [37]. This evidence concerns the gene CASC2 and Sepsis.