In our study, we demonstrated that nasopharyngeal carcinoma tumor cells with high IGF1-R expression have a high propensity for bone metastasis, and IGF-1 secreted by osteoclasts promotes the proliferation of tumor cells in the bone marrow through the IGF-1R/AKT/S6 signaling pathway. This evidence concerns the gene AKT1 and nasopharyngeal carcinoma.