The most frequently extracted keywords included “ON,” “MRI,” “diagnosis,” “risk,” “clinical-features,” “cerebrospinal-fluid (CSF),” “optic neuropathy,” “clinically isolated syndrome,” “neuropathy” and “prevalence.” Herein, the discussion mainly focuses on MS-ON, AQP4-ON and MOG-ON. This evidence concerns the gene AQP4 and Optic neuropathy.