Knockdown of CXCL1 in GBM cells abrogated the protumorigenic effects of SnAs and extended the survival time of pre‐irradiated mice bearing GL261 or G422 cells (GL261: 75 or 71 days vs 31 days, WBRT+sh‐CXCL1‐1/2 vs WBRT+sh‐NC, respectively, P < 0.01; G422: 55 or 45 days vs 24 days, WBRT+sh‐CXCL1‐1/2 vs WBRT+sh‐NC, respectively, P < 0.01; Figure 5G). This evidence concerns the gene CXCL11 and glioblastoma.