CDKN2A and neoplasm: Clearance of P16INK4A+ SnCs extends the survival time of preirradiated mice bearing GL261 cells (GL261: 62 days versus 33 days, TMX+DT versus TMX+Saline, respectively, P < 0.001; Figure 2F), accompanied by decreased microvascular and cellular proliferation in the tumor area (Figure 2G,H).