Both exome‐wide association study and genome‐wide DNA methylation analysis hinted the involvement of C21orf58 in cancer.[7, 14] Based on the analysis results of ULCAN database, we found that C21orf58 expression was upregulated in HCC with higher pathological grade and tumor stage (Figure 1A,B), which implied that C21orf58 expression was abnormal and associated with HCC progression. Here, C21orf58 is linked to cancer.