Our study demonstrated that the expression of C21orf58 was significantly increased in HCC tissues, which was consistent with the expression pattern in breast cancer.[6b] C21orf58 expression positively correlated with clinical tumor size, negatively associated with HCC patients’ prognosis, which suggested that C21orf58 might be an oncogene in HCC. The gene discussed is C21orf58; the disease is breast carcinoma.