Our study demonstrated that the expression of C21orf58 was significantly increased in HCC tissues, which was consistent with the expression pattern in breast cancer.[6b] C21orf58 expression positively correlated with clinical tumor size, negatively associated with HCC patients’ prognosis, which suggested that C21orf58 might be an oncogene in HCC. This evidence concerns the gene C21orf58 and hepatocellular carcinoma.