Heat shock proteins (HSPs) are rational targets used for the development of new cancer therapeutics, as cancer cells depend on the increased levels of HSPs to maintain their unstably elevated proliferative and metabolic states.[48] The transport of Ca2+ from the ER to the mitochondria is mediated by the IP3R‐GRP75 complex in the MAM structure, which is critical for maintaining cellular bioenergy. This evidence concerns the gene HSPA9 and cancer.