CK8 is cytokeratin 8 (CK8), associated with increased invasiveness of the tumor in vitro and in vivo, and is preferentially expressed in NSCLC.[42] We found that compared to cKp lung tumor tissue, cPD‐KI Kp lung tumor tissue and metastatic thyroid tissue showed higher expression of lung metastasis associated protein CK8 through immunohistochemistry (Figure S2C, Supporting Information). This evidence concerns the gene NPPA and non-small cell lung carcinoma.