The novel cancer related multifunctional protein MR‐1 (Myofrillogenes regulator‐1) can stabilize the expression of Notch3‐ICD (NICD3) in the cytoplasm through ITCH, which can upregulate many genes related to metastasis to promote the metastasis of NSCLC cells. Here, ITCH is linked to non-small cell lung carcinoma.