It was revealed that the right hippocampal microinjection of HMPWCs in AD‐like rats significantly improved spatial learning and memory in these rats by synergistically relieving oxidative stress, reducing p‐Tau levels via the activation of AKT/GSK‐3β and deactivation of ERK, and inhibiting the activation of microglia and astrocytes and release of pro‐inflammatory cytokines.[227] Oral administration may offer advantages over invasive injection regarding patient compatibility and gut‐brain regulation. This evidence concerns the gene MAPT and Alzheimer disease.