Remarkably, the low‐dose PHT@TGN‐HBc (0.2 mg PHT kg−1) relieved seizures in PHT‐resistant mice, while high doses of free PHT proved ineffective.[259] More recently, to overcome PHT resistance, PHT was incorporated into calcium phosphate NPs modified with PEGylated BBB‐penetrating TAT peptide, termed CaP@PHT‐PEG‐TAT. This evidence concerns the gene KRT88P and pulmonary hypertension, primary, 1.