PKM and cancer: For example, ASOs that promote a shift from STAT3α to STAT3β exhibit good anti‐tumor activity both in vitro and in vivo,[33] and ASOs that switch PKM splicing from the cancer‐associated PKM2 isoform to the PKM1 isoform reverse the Warburg effect and inhibit tumor growth.[34] Also, our group previously developed ASOs that mediate BCL2L12 exon 3 skipping and suppress ovarian tumor growth.[15] In this study, we developed ASOs based on the binding sites of PQBP1 in the pre‐mRNA of BAX.