S100P and cancer: S100P is a member of the S100 calcium‐binding protein family that has been reported to have intracellular and extracellular functions.[20] S100P is overexpressed in a variety of cancers, including NSCLC, and its expression is associated with metastasis, drug resistance, and poor clinical outcome.[21, 22] Meta‐analysis of cDNA array data revealed that S100P was one of five genes dysregulated in lung cancer.[23] Moreover, S100P had been demonstrated to be overexpressed in metastatic tissues of NSCLC.[24] Moreover, knockdown of S100P inhibited cell migration in highly invasive NSCLC cells.[25]