AKAP12 and lung cancer: Nevertheless, other studies suggested that RBMS1 might be a potential tumor suppressor.[18, 19] RBMS1 suppresses colon cancer metastasis through targeting stabilization of multiple genes, including the tumor suppressor AKAP12 and a WNT pathway interacting protein, SDCBP.[18] In our previous study, we found that RBMS1 is upregulated in lung cancer and depletion of RBMS1 inhibits lung cancer cell growth.[15] However, the role of RBMS1 in the regulation of NSCLC metastasis has not been documented yet.