Compelling evidence has demonstrated that exosomal miR-21-5p suppressed Krev interaction trapped protein 1 (KRIT1) in recipient HUVECs and subsequently activated the β-catenin signalling pathway and increased their downstream targets VEGFa and Ccnd1, enhancing angiogenesis and vascular permeability in CRC [113]. Here, KRIT1 is linked to colorectal carcinoma.