KLF4 and colorectal carcinoma: Moreover, miR-25-3p, which is carried by exosomes derived from CRC, reportedly increases the expression of VEGFR2 and decreases the levels of ZO-1, occludin and claudin-5 in endothelial cells by targeting Krüppel-like factor 2 (KLF2) and Krüppel-like factor 4 (KLF4), consequently promoting vascular permeability and angiogenesis [108].