Shihua Wang et al. found that HCC cell HepG2-derived exosomes could activate various kinases, such as AKT, STAT5α, GSK3 alpha/beta, p38 alpha, and ERK1/2, as well as the NF-κB signalling pathway in adipocytes to promote tube formation [135]. Here, AKT1 is linked to hepatocellular carcinoma.