TIMP3 and colorectal carcinoma: In contrast, an antiangiogenic role has been demonstrated for circular FNDC3B, which has been found to be involved in microvesicles secreted by CRC cells and suppresses angiogenesis by directly regulating miR-937-5p to induce the expression level of the tumour-suppressor TIMP3, which inhibits the angiogenesis of CRC [120].