Furthermore, poly (A) binding protein cytoplasmic 1 (PABPC1) activates the IFN/IFI27 signalling pathway to enhance oesophageal squamous cell carcinoma (ESCC) proliferation; at the same time, PABPC1/IFI27 can increase exosomal miRNA-21-5p to promote angiogenesis by inhibiting CXCL10 [89]. The gene discussed is PABPC1; the disease is esophageal squamous cell carcinoma.