Seven compounds that inhibit the formation of the Skp2-Skp1 complex have been identified through virtual high-throughput screening and in vitro screening, with SZL-P1-41, in particular, exhibiting potent inhibition of the construction of the Skp2-Skp1 complex in relevant assays and inhibiting tumor growth effectively in vivo [42, 43]. Here, SKP1 is linked to neoplasm.