The NDC, Nb-TROP2-HAS-MMAE, consists of a nanobody against TROP2 and human serum albumin (HSA), which, after intracellular transfer to lysosomes, releases MMAE in the cell and induces cell apoptosis in TROP2-positive pancreatic cancer cells. The gene discussed is TACSTD2; the disease is familial pancreatic carcinoma.