Through the regulation of MMPs, serine proteases and cathepsins, TAMs induce angiogenesis, degrade basement membranes, and secrete pro-angiogenic factors, cytokines and chemokines including VEGF, CXCL8, MMP7, MMP9 and MMP12, facilitating the formation of the tumor vascular networks131. This evidence concerns the gene VEGFA and neoplasm.