Ling et al.85 proved that exosomes produced from large diffuse B-cell lymphoma (DLBCL) might inhibit epirubicin-induced apoptosis in DLBCL cells, stimulate the GP130/STAT3 pathway, upregulate IL-10, CD206, and CD163 expression, and polarize TAMs toward M2 phenotype in order to enhance epirubicin tolerance in DBCL. The gene discussed is STAT3; the disease is diffuse large B-cell lymphoma.