TMB was significantly higher in NF1-mutated versus NF1 wild-type (WT) lung adenocarcinoma (p < 0.0001) with a mean TMB at 14.1 mut/Mb [0.7–65.7] in NF1-mutated tumors versus 6.5 mut/Mb [0.0–96.5] in NF1 WT tumors (Fig. 1, Supplementary Fig. 1). This evidence concerns the gene NF1 and lung adenocarcinoma.