ARRB2 and adenocarcinoma: Analysis of GEO databases also demonstrated elevated ARRB2 expression in tissues with higher Gleason scores (Fig. 4H).In addition, CRPC tissues exhibited significantly higher ARRB2 expression compared to primary tumor tissues (Fig. 4I, J), and ARRB2 was found to be more highly expressed in NEPC tissues compared to adenocarcinoma PCa tissues (Fig. 4K).