PKM and non-small cell lung carcinoma: Furthermore, circEPB41L2 inhibited glucose uptake and lactate production, progression and metastasis in NSCLC by binding to the RRM1 domain of the PTBP1 protein to promote its interaction with the E3 ligase TRIP12, which induced PTBP1 polyubiquitylation and degradation and blocked PTBP1-induced PKM2 and Vimentin accumulation.