PTBP1 and non-small cell lung carcinoma: Our findings highlight the circEPB41L2-dependent mechanism that modulates the “Warburg Effect” to inhibit the progression and metastasis of NSCLC by binding to the crucial motif of an RNA-binding protein for ubiquitination via a novel ubiquitin ligase, thus expanding the understanding of the multifaceted functions of circular RNAs in NSCLC progression.