Furthermore, IHC assay results exhibited that E-cadherin expression was dramatically elevated but expression of PTBP1 and Vimentin was obviously reduced in circEPB41L2-overexpressing tumour tissues compared to controls (Fig. 7I), suggesting that circEPB41L2 inhibits NSCLC growth and metastasis by blocking PTBP1-mediated Vimentin activation and E-cadherin inactivation in vitro and in vivo. This evidence concerns the gene PTBP1 and neoplasm.