To further investigate the role of HSL in regulating glioblastoma cells proliferation, HSL-downregulating tumor cell lines (transfection of siRNAs into both SNB19 and LN229 cells) were established (Fig. 2A), and the designed interfering chain si‐HSL-1 showed the highest interference efficiency and was selected for subsequent experiment (Fig. 2B). This evidence concerns the gene DCPS and neoplasm.