Consistent with this, our experiments also confirmed elevated mRNA expression levels of Nrf2, NQO1, HO-1, GCLC, and GCLM in HD mouse cell lines, where Q111 cells exhibited significantly higher expression compared to Q7 (Supplemental Fig. 3), indicating activation of the Nrf2-ARE anti-oxidative defense system in HD cells. The gene discussed is GCLC; the disease is Huntington disease.