MPPE1 and neoplasm: In addition to identifying an important role for cDC1 licensing in promoting robust intrahepatic CD8+ T cell immunity, these findings challenge the paradigm that cognate DC licensing is restricted to SLOs1,27,28, and suggest that these molecular signals, critical for host protection against intracellular pathogens and tumours, can also be transferred to CD8+ T cells in a peripheral tissue.