Moreover, the mRNA expression of Hhip, Adrb2, Rac2, and Adcy7 was elevated in HF BMS group, indicating activation of the cAMP signaling pathway (P < 0.01, P < 0.05, P < 0.01, P < 0.05, respectively; Fig. 8H–K). Here, RAC2 is linked to hydrops fetalis.