An earlier scRNA-Seq study by the same group (54) described in NSCLC the signature of a Treg population (cluster 9) mostly composed of tumor-infiltrating Tregs and, to a lesser extent, of NLT Tregs; this signature was enriched in TNFR2-costimulated tTregs (Figure 7, A and B). The gene discussed is TNFRSF1B; the disease is neoplasm.