INS and type 2 diabetes mellitus: The Manchester Intermittent versus Daily Diabetes App Study (MIDDAS), a study comparing an ILED and a continuous low-energy diet in T2D conducted in our unit, has shown the feasibility and safety of an ILED (800 kcal for 2 days/week) in patients with T2DM and obesity, including those using insulin.18 At the end of the study, approximately 70% of participants in the ILED group completed the study and achieved a 6% reduction in their baseline body weight.