Using a publicly available transcriptional human dataset composed of sorted normal B cells and B cell lymphomas,32 we identified a significant increase in CD80 and CD86 transcript abundance in non-malignant germinal center B cells (centroblasts, centrocytes) compared with non-germinal center B cells (naive B cells, memory B cells, plasma cells). The gene discussed is CD80; the disease is B-cell non-Hodgkin lymphoma.