CD19 and diffuse large B-cell lymphoma: In further cytotoxic in vitro studies performed with CD19+ DLBCL cell lines displaying CD80lowCD86high, CD80highCD86low, or even CD80lowCD86low expression levels, CAR/CCR T cells were at least as effective as T cells genetically engineered to express the CD19-specific CAR constructs of the 1st Gen or 2nd Gen.