The survey of putative PAX8-regulated genes presented here is likely to be of interest given the emerging evidence of PAX8-dependency in the development of adult human cancers including renal cell clear cell carcinoma and ovarian cancer50,51; however, we note that these in silico analyses are predictive and further studies directly probing PAX8 chromatin binding are required to better understand the PAX8 target gene repertoire. Here, PAX8 is linked to clear cell renal carcinoma.