The upregulation of ACSL4 expression following co-culture suggests that EMT may influence the sensitivity of ESCC cells to ferroptosis by activating the yes-associated protein 1 (YAP1) and the WW domain-containing transcription regulator protein 1 (WWTR1) in the Hippo pathway [37]. Here, WWTR1 is linked to esophageal squamous cell carcinoma.