In addition, knockdown of SPOP effectively reversed the effects of BCLAF1 knockdown on apoptosis, cell cycle, and secreted cytokines of Jurkat cells (Fig. 6d–k, Supplemental Fig. 6b–i), indicating that BCLAF1 partially depended on SPOP to participate in the suppression of the anti-tumor immune microenvironment. The gene discussed is BCLAF1; the disease is neoplasm.