Whilst OGR1 expression is increased in bronchial smooth muscle cells in an ovalbumin antigen-challenged murine asthma model [10], it is downregulated in fibroblasts from patients with idiopathic pulmonary fibrosis [65], which promotes myofibroblast differentiation, suggesting that OGR1 has anti-fibrotic effects in lung fibroblasts [56]. This evidence concerns the gene GPR68 and asthma.